Description
Procalcitonin is a peptide hormone mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock.
Recombinant procalcitonin comprises a 114aa fragment (aa3-116) corresponding to the unprocessed procalcitonin protein and is expressed in E. coli with an amino- terminal hexahistidine tag